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The use of bolus 5-fluorouracil (5-FU) as a short-term infusion over 10-30min is increasing at the cost of a push injection, mainly due to practical advantages. Since even a short prolongation of the administration time results in lower 5-FU peak and area under the curve (AUC) levels, there might be a risk of decreased efficacy. The aim of this study was to compare a rapid intravenous (i.v.) 5-FU...
Background: The extent to which chemotherapy may relievetumour-related symptoms, improve quality of life and prolong survival inpatients with gastric cancer is not known in spite of the extensive use ofthis treatment modality. The aim of this study was to estimate any gain in thequantity and quality of life produced by chemotherapy in these patients. Patients and methods: Between January 1991 and...
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