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The Wnt-responsive transcription factors Tcf1 and Lef1 are well-known for their roles in lymphocyte development. In this issue of Immunity, Yu et al. (2012) report that Tcf1-deficient mice develop aggressive T cell lymphomas that are characterized by high Lef1 expression.
Eukaryotic cells have evolved a large variety of chromatin remodeling complexes to control gene expression. In this issue, define an essential role for the BAF complex during thymocyte development by conditional deletion of one of its components, Brahma-related gene (Brg).
Families of clonally expressed major histocompatibility complex (MHC) class I-specific receptors provide specificity to and regulate the function of natural killer (NK) cells. One of these receptors, mouse Ly49A, is expressed by 20% of NK cells and inhibits the killing of H-2D d but not D b -expressing target cells. Here, we show that the trans-acting factor TCF-1 binds to two sites...
Lymphoid enhancer factor 1 (LEF-1) and T cell factor 1 (TCF-1) are closely related transcription factors that are both expressed during murine T cell differentiation and that regulate the T cell receptor α (TCRα) enhancer in transfection assays. Targeted gene disruption of either the Tcf1 or Lef1 gene in mice did not affect TCRα gene expression and resulted in an incomplete defect or no defect in...
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