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In cultured bovine adrenal chromaffin cells, where Akt1 is the predominant isoform over Akt2 and Akt3, chronic (≥12 h) treatment with 1–20 mM LiCl, an inhibitor of glycogen synthase kinase-3, decreased Akt1 level by ~52% (EC 50 =3.7 mM; t 1/2 =l2 h); it was associated with LiCl-induced increased levels of Ser 9 -phosphorylated glycogen synthase kinase-3β (~37%) and β-catenin...
In cultured bovine adrenal chromaffin cells, 12-h treatment with 1–20 mM LiCl, an inhibitor of glycogen synthase kinase-3 (GSK-3), increased Ser 9 phosphorylation of GSK-3β by ∼44%, while decreasing insulin receptor substrate-1 (IRS-1) and IRS-2 protein levels by ∼38 and ∼62% in a concentration-dependent manner. Treatment with SB216763 (0.1–30 μM for 12 h), a selective inhibitor of GSK-3,...
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