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It has previously been shown that patients with haemophilia A may develop non‐neutralizing anti‐factor VIII (FVIII) antibodies (NNA) that escape detection by the Bethesda assay, but are detected using immune‐based assays. We and others found NNAs to be directed not only towards non‐functional parts of the protein, but towards all regions of the FVIII protein. We also showed a heterogeneous antibody...
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