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Mice lacking the stress-signaling kinase SEK1 die from embryonic day 10.5 (E10.5) to E12.5. Although a defect in liver formation is accompanied with the embryonic lethality of sek1 -/- mice, the mechanism of the liver defect has remained unknown. In the present study, we first produced a monoclonal antibody specifically recognizing murine hepatoblasts for the analysis of liver development...
A hemizygous deletion ofLIS1,the gene encoding α Lis1 protein, causes Miller–Dieker syndrome (MDS). MDS is a developmental disorder characterized by neuronal migration defects resulting in a disorganization of the cerebral and cerebellar cortices. α Lis1 binds to two other proteins (β and γ) to form a heterotrimeric cytosolic enzyme which hydrolyzes platelet-activating factor (PAF)...
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