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A method using ultrahigh‐performance liquid chromatography–tandem mass spectrometry was developed, validated, and applied to simultaneously determine plasma methotrexate (MTX) and 7‐hydroxy‐methotrexate (7‐OH‐MTX) in 117 patients with central nervous system (CNS) lymphoma. The ion transitions utilized were m/z 455.2 > 308.2 for MTX and m/z 471.2 > 324.1 for 7‐OH‐MTX. Samples were prepared through...
Plasma concentrations of nicotine and its active metabolite cotinine are highly correlated with its biological effects. A UHPLC–MS/MS method was developed, validated and applied for nicotine and cotinine analysis in mice plasma. Chromatographic separation was achieved on a BEH HILIC column using acetonitrile (0.1% formic acid) and 10 mm ammonium formate as mobile phase. The gradient elution was performed...
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