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Recent advances in digital microfluidics have enabled lab-on-a-chip devices for DNA sequencing, immunoassays, clinical chemistry, and protein crystallization. Basic operations such as droplet dispensing, mixing, dilution, localized heating, and incubation can be carried out using a 2-D array of electrodes and nanoliter volumes of liquid. The number of independent input pins used to control the electrodes...
On-line testing offers a promising method for detecting defects, fluidic abnormalities, and bioassay malfunctions in microfluidic biochips. To reduce product cost for disposable biochips, testing steps and functional fluidic operations must be implemented on pin-constrained designs. However, previous testing methods for pin-constrained designs do not optimize test schedules to reduce the number of...
The implementation of bioassays in pin-constrained biochips may involve pin-actuation conflicts if the concurrently implemented fluidic operations are not carefully synchronized. We propose a two-phase optimization method to identify and synchronize the fluidic operations that can be executed in parallel. The goal is to implement these fluidic operations without pin-actuation conflict, and minimize...
The multiplexed in-vitro measurement of glucose and other metabolites in human physiological fluids is of great importance for the clinical diagnosis of metabolic disorders. We present a design technique for optimizing an n-plex bioassay on an electrowetting-based digital microfluidic lab-on-chip. The n product droplets of the n-plex bioassay are detected using a photomultiplier tube located at the...
Recent advances in droplet-based digital microfluidics have enabled biochip devices for DNA sequencing, immunoassays, clinical chemistry, and protein crystallization. Since cross-contamination between droplets of different biomolecules can lead to erroneous outcomes for bioassays, the avoidance of cross-contamination during droplet routing is a key design challenge for biochips. We propose a droplet-routing...
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