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Butyrate, a histone deacetylase inhibitor, has several therapeutic applications, including cancer. However, the effect of butyrate in HBV replication is not known so far. It was hypothesized that butyrate might inhibit HBV replication and host cell proliferation via SIRT‐1. It was found that the increased expression of SIRT‐1 in Hep G2.2.15 cells (HBV expressing cells) than Hep G2 cells. Next the...
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