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Background: Menin is a tumor suppressor encoded by Men1 that is mutated in the human-inherited tumor syndrome — multiple endocrine neoplasia type 1. Menin binds to estrogen receptors (ER) to enhance estrogen activity in breast cancer cells. Aim: Our clinical study showed that the outcome in the case of menin-positive tumors was worse than in the case of menin-negative tumors. We examined the role...
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