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The cytotoxicity of 15-nm and 46-nm silica nanoparticles was investigated by using crystalline silica (Min-U-Sil 5) as a positive control in cultured human bronchoalveolar carcinoma-derived cells. Exposure to 15-nm or 46-nm SiO 2 nanoparticles for 48 h at dosage levels between 10 and 100 μg/ml decreased cell viability in a dose-dependent manner. Both SiO 2 nanoparticles were more cytotoxic...
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