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BACKGROUND
Expanding quantities of mesenchymal stem cells (MSCs) sufficient to treat large numbers of patients in cellular therapy and regenerative medicine clinical trials is an ongoing challenge for cell manufacturing facilities.
STUDY DESIGN AND METHODS
We evaluated options for scaling up large quantities of bone marrow–derived MSCs (BM‐MSCs) using methods that can be performed in compliance...
BACKGROUND
Clinical trials involving mesenchymal stem cell (MSC) therapy have variable outcomes. We hypothesize this is largely attributed to donor‐to‐donor variability and tissue of origin.
STUDY DESIGN AND METHODS
We examined proliferation rates, cytokine secretion profiles, and differentiation capability of seven bone marrow–derived MSCs (BM‐MSCs) and 16 adipose tissue–derived MSCs (AD‐MSCs)...
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