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BackgroundThe two common sialic acids (Sias) in mammals are N‐acetylneuraminic acid (Neu5Ac) and its hydroxylated form N‐glycolylneuraminic acid (Neu5Gc). Unlike most mammals, humans cannot synthesize Neu5Gc that is considered foreign and recognized by circulating antibodies. Thus, Neu5Gc is a potential xenogenic carbohydrate antigen in bioprosthetic heart valves (BHV) that tend to deteriorate in...
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