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In the context of the prosperous development of Proteomics in life science, protein quantification, especially these based on Mass Spectrometry (short for MS) method, becomes an essential part of research. In our previous work, we developed a new software package called QuantWiz for high performance Liquid Chromatography (short for LC)-MS-based label-free protein quantification. We solved those problems...
The functional knowledge of cancer proteins and cancer pathways is currently limited and not detailed enough, remaining as a major hurdle to cancer studies. Particularly, many cancer proteins are only annotated to high-level general GO categories. Here, we apply an efficient algorithm, by constructing function-specific protein-protein interaction sub-networks, to find finer functions of the cancer...
Nowadays proteomics becomes more and more popular in life science. Protein quantification, especially based on mass spectrometry (short for MS) method, is perceived as an essential part of research on proteomics. There have been some algorithms and software for protein quantification based on MS. But they have difficulties on portability, applicability and longtime running. To solve these problems,...
Cyberworlds could be a platform for both research and e-learning particularly in research intensive disciplines such as biology, physical chemistry, molecular medicine, biophysics, structural biology, bioinformatics, etc. The computer simulation of assembling molecules has been studied intensively in the field of computer-aided rational drug design. The assembly of molecules in a three-dimensional...
We analyzed the Hurst exponent for the amino acid sequences of proteins and secretory signal peptides using the aggregated variance method. Then the diversification entropy of the sequences was calculated. The numeralization of the amino acid sequences are according with the three amino acid indices: EIIP, polarity and accessible surface area. The results show that when an amino acid sequence coding...
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