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Although α 1L -adrenoceptor is recognized as a target of α 1 antagonist therapy for benign prostatic hyperplasia, the most common techniques, such as immunohistochemistry and in situ hybridization, are not applicable to examine α 1L -AR vs α 1A -AR tissue distribution because α 1L -AR is now considered another phenotype sharing the α 1A -AR gene and...
Silodosin (KMD-3213 or [(-)-1-(3-hydroxypropyl)-5-[(2R)-2-({2-[2-(2,2,2trifluoroethoxy)phenoxy]ethyl}amino)propyl]-2,3-dihydro-1H-indole-7-carboxamide]) (Kissei Pharmaceutical Co., Ltd., Matsumoto, Japan) is a selective antagonist for α-1A and α-1L adrenoceptors. Using this tritiated ligand the 2 α-1 adrenoceptors were examined in binding studies with intact tissue segments and membrane preparations...
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