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We present an unusual pediatric case of invasive upper tract urothelial carcinoma with an associated genetic predisposition. A 14-year-old female presented with intermittent right flank pain, and was found to have a poorly functioning hydronephrotic right kidney. Laparoscopic nephrectomy was performed. Pathology demonstrated upper tract urothelial carcinoma, and she subsequently underwent completion...
To investigate the association of cannabis use and tobacco smoking on the incidence of bladder cancer within the California Men's Health Study cohort.We evaluated the records of 84,170 participants in a multiethnic cohort of men aged 45-69 years. Information on demographic and lifestyle factors including smoking history and cannabis use was collected using mailed questionnaires between 2002 and 2003...
To report changes in grade and stage between initial diagnostic and repeat biopsies or resection for urothelial carcinoma (UTUC) and investigate the consequences for endoscopic management. Ureteroscopic management of upper tract UTUC is an alternative to nephroureterectomy, which is less invasive and preserves renal function. However, concerns about potential understaging, inaccurate grading, incomplete...
Urologists are integrally involved in the management of acute kidney injury (AKI), which is common after renal surgery or secondary to postrenal (obstructive) etiologies. The measurement of serum creatinine is a suboptimal indicator of AKI because it lags behind acute changes in renal function. Recent advances indicate that serum/urine biomarkers will prove useful for early detection of AKI, analogous...
The management of urological emergencies during pregnancy presents unique clinical challenges for the treating physician. Clinical signs and symptoms are often subtle while diagnostic and therapeutic options are limited in treating patients to avoid fetal morbidity. A high index of suspicion with early diagnosis and treatment are essential for the management of genitourologic emergencies in pregnant...
To assess the safety and technical feasibility of laparoscopic partial nephrectomy in patients aged ≥80 years at our institution to determine whether this treatment modality may be justifiable in select octogenarians. As the US population ages, an increasing number of elderly patients with renal masses are considered for partial nephrectomy. We present our experience with laparoscopic partial nephrectomy...
Although renal vein invasion and/or inferior vena cava extension occurs in 4%-10% of patients with renal cell carcinoma, involvement of the gonadal vein is uncommon. We present a case of a patient with unresectable metastatic renal cell carcinoma invading the gonadal vein, who was initially treated with targeted molecular therapy.
To report our experience with laparoscopic radical prostatectomy for the treatment of localized prostate carcinoma in 3 renal transplant recipients.We retrospectively identified all patients who had undergone laparoscopic prostatectomy for clinically localized prostate cancer between 1999 and 2006 at our institution (n = 1067). Of these patients, 3 were renal transplant recipients (dual cadaveric...
Premature ejaculation is the most common male sexual dysfunction and, yet, no approved effective therapies are currently available. We studied the in vivo effectiveness of hyperforin (HF), a concentrated extract of Hypericum perforatum in an experimental model for the expulsion phase of ejaculation in anesthetized rats.The ejaculation model involved inducing rhythmic bulbospongiosus (BS) muscle contractions...
To present the long-term outcome of deceased-donor kidney transplantation in prune belly syndrome (PBS). All the PBS transplant patients had undergone extensive pretransplant urologic tract preparation. We also compared the patient and graft survival in an age-matched control group who underwent transplantation for end-stage renal disease due to a nonposterior urethral valve in our urology department...
Control of bleeding from the renal parenchyma remains one of the challenges of laparoscopic partial nephrectomy. If adjuvant measures fail, packing of the surgical bed may achieve hemostasis. We report a novel series of temporary laparoscopic packing of the surgical bed with minimally invasive kidney surgery. Technique and potential complications are also discussed.
Objectives. To compare the relative strength of fixation using bone anchors (BAs) compared with direct suture placement into the periosteum.Methods. The anterior bony pelvis was harvested from 21 female cadavers. In each pelvis, BA suture fixation was performed using Cinch anchors on one side of the pubic bone and direct periosteal suture fixation (PSF) on the contralateral side of the same pelvis...
A young patient with testicular germ cell tumor presenting with inferior vena cava thrombus extending into the right heart with free-floating thrombus in the right ventricle and a simultaneous epidural spinal cord compression is presented. Due to the perceived high risk of embolization and the urgent need to begin systemic chemotherapy, he was managed with tumor thrombectomy utilizing cardiopulmonary...
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