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A mathematical model describing the relationship between uninfected hepatocytes, infected hepatocytes, HBV, CD8+ T-cells(CTL), antigen presenting cells, CD4+ T cells (Th1 and Th2), plasma cells, antibody, and so on was established to explain the mechanism of HBV infection. The mathematical analysis result shows the condition of how can the immune system eliminate HBV entirely from the body. The model...
In order to understand the role of monocytes and macrophages (MPhi) in the pathogenesis of SARS, we detect pathological changes, cell apoptosis and expression levels of CD68, Mac387, CD25, ACE2 and S protein in the specimens of lungs, spleen and lymph nodes. Plenty of infiltrating MPhi could be seen in a number of tissues including the alveolus cavity, the lymphatic sinus in lymph nodes and the splenic...
Cell surface molecule CD44 of human brain microvascular endothelial cells (HBMEC) is the receptor of Cryptococcus neoformans during the infection. We performed microarray analysis and used principle component analysis to examine gene profiles of HBMEC in responses to C neoformans infection. The CD44 levels increases, peaking at the 4-hour time point and then declined gradually. Seventy genes displayed...
Cryptococcus neoformans is able to infect brain microvascular endothelial cells (BMEC). We performed microarray analysis of the changes in gene expression of human BMEC (HBMEC) to dissect the pathogenesis of this infection. Changes in mRNA levels were monitored at 0, 4, 8, 12, 16, 20 and 24 hours. Principal component analysis (PCA) revealed a fluctuation of gene groups during the pathogen-host interaction...
Nowak's model of the human immunodeficiency virus (HIV) infection has been extensively and successfully used to simulate the interaction between HIV and cytotoxic lymphocyte (CTL)-mediated immune response. However, such model is not available for hepatitis B virus (HBV). As the enhanced recruitment of virus-specific CTLs into the liver has been an important novel concept in the pathogenesis of hepatitis...
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