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The incidence of atrial fibrillation (AF) is correlated with decreased levels of testosterone in elderly men. Late sodium current may exert a role in AF pathogenesis.The purpose of this study was to explore the effect of testosterone deficiency on AF susceptibility and the therapeutic effect of late sodium current inhibitors in mice.Male ICR mice (5 weeks old) were castrated to establish a testosterone...
Low-level carotid baroreflex stimulation (LL-CBS) appears to have a potential antiarrhythmogenic effect.The purpose of this study was to investigate effects of short-term LL-CBS on an atrial fibrillation (AF) canine model.Group 1 (LL-CBS in the 6 hour-rapid atrial pacing model): Anesthetized dogs underwent 6 hours of rapid atrial pacing (RAP) with concomitant LL-CBS in last 3 hours (LL-CBS group;...
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