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In acutely isolated rat primary sensory neurons, the effects of caffeine on GABA receptormediated current (IGABA) were investigated using a whole-cell patch clamp technique. We found that applications of GABA (10-1000 μM) induced inward currents in a concentration-dependent manner; the currents manifested obvious desensitization. Pretreatment with caffeine (0.01-100 μM) suppressed IGABA in a noncompetitive...
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