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Recent data suggest that gp120, a human immunodeficiency virus-1 (HIV-1) coat glycoprotein that is secreted by HIV-infected cells, is neurotoxic, and that this toxicity is mediated, at least in part, by activation ofN-methyl-d-aspartate-type excitatory amino acid receptors. To test this hypothesisin vivo, we examined the neurotoxicity of gp120 injected intrahippocampally, alone or co-injected with...
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