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ObjectivesAs a switch from chemokine (C‐C motif) receptor 5 [CCR5 (R5)] to chemokine (C‐X‐C motif) receptor 4 [CXCR4 (X4)] HIV‐1 tropism is associated with symptomatic and AIDS stages of infection, while chemokine receptor gene variants modify the tempo of HIV disease progression, we aimed to analyse the association between pretreatment HIV‐1 tropism and chemokine polymorphisms known to restrict disease...
ObjectiveProspective pharmacogenetic screening for the human leucocyte antigen (HLA) B*5701 allele can significantly reduce the number of cases of abacavir‐related hypersensitivity among HIV‐infected patients treated with this drug. The aim of this study was to establish the frequency of the HLA B*5701 variant in HIV‐infected Poles.
MethodsThe sequence‐specific primer (SSP) test was used to assess...
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