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To test the hypothesis that differences in subfractions of circulating lipoproteins between diabetic and non-diabetic subjects exist and might contribute to the increased risk for atherosclerosis in type II diabetics.LDL isolated from diabetic (D) and control subjects (N) were separated by FPLC into five subfractions (L1–L5). The fractional distributions of N- and D-LDL were not different, but the...
Electronegative low density lipoprotein (LDL) subfractions are cytotoxic to endothelial cells. To continue our study of homozygotic familial hypercholesterolemic (FH)-LDL, we report the effects of FH-LDL subfractions (FH-L1 to FH-L5) on the angiogenic processes in cultured endothelial cells.Subconfluent bovine aortic endothelial cells (BAEC) were treated with LDL subfractions (20μg/ml), and the effects...
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