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Male Wistar rats were given nickel (II) chloride (NiCl2 • 6 H2O) with drinking water (300 or 1200 ppm Ni for 90 days). Urine volume and nickel, zinc, copper, calcium and inorganic phosphorus were measured in 24 h urine after 45 and 90 days of exposure. The results demonstrate that relatively low-level oral exposure (300 ppm Ni) induces an increase of urinary Ni excretion (p < 0.001), but no significant...
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