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Breeding of (outbred) selective lines of laboratory mouse was initiated in Warsaw University of Life Sciences about 40 years ago. It bred Heavy (C) and Light (L) mice selected opposite for body weight at weaning (21st day of life), S mice line selected for higher testes weight, and control (K) mice without selection. All lines have identical genetic background, but different directions of selections...
Experiments were performed on 180 mice from two lines dubbed light (L) and heavy (C), selected divergently for body weight over 108 generations. The main hypothesis was that the changes occurring in body weight and muscle weight as a result of directed divergent selection could be associated with changes in the transcription of some miogenic genes and/or with the level of proteins regulating myogenesis...
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