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Adult bone marrow-derived mesenchymal stem cells (hMSCs) display a spectrum of functional properties. Transplantation of these cells improves the clinical outcome in experimental models of cerebral ischemia and spinal cord injury. Therapeutic effects have been reported in stroke after the systemic delivery of MSCs. A minimally invasive, intraarterial route is an attractive method for stem cell transplantation...
The aim of the study was to evaluate therapeutic effectiveness of intra-arterial infusion of human umbilical cord blood (HUCB) derived cells at different stages of their neural conversion. Freshly isolated mononuclear cells (D-0), neurally directed progenitors (D-3) and neural-like stem cells derived from umbilical cord blood (NSC) were compared. Focal brain damage was induced in rats by stereotactic...
Birth asphyxia remains a frequent cause of perinatal morbidity and mortality. During perinatal hypoxic-ischemic (HI) brain injury neuronal cells are damaged and lose their function or die. Recently, it has become clear that ischemic brain injury stimulates neural stem cell proliferation and differentiation in cerebral neurogenic areas – subventricular zone (SVZ) and dentate gyrus (DG) of the hippocampus...
The methylmercury chloride (MeHgCl) is known to cause developmental neurotoxicity in humans. This neurotoxic reagent can induce cell death due to several cellular mechanisms including phosphorylation dependent pathways and disruption of microtubule assembly. The non transformed neural stem cell line obtained from human cord blood (HUCB-NSC) has been previously shown to be susceptible to MeHgCl in...
Stem cell transplantation offers an exciting new therapeutic avenue for stroke not only to prevent damage, which has been the focus of conventional therapeutic strategies, but also to actually repair the injured brain. Indeed, exogenous stem cell grafting in animal models of CNS damage improves function by replacing the lost neurons. However, therapeutic mechanism different from the expected contribution...
Searching for a reliable source of alternative neural stem cells for experimental treatment of neurological disorders we have established neural stem cell line derived from human umbilical cord blood (HUCB-NSC) (Buzanska et al. 2006). These cells have been shown to differentiate along neuronal and glial lineages in the promoting in vitro conditions. In the current study we transplanted HUCB-NSC into...
The morphometrical and volumetrical changes of the middle cerebral artery (MCA) during the fetal period of development were analyzed by digital-image analysis system (DIAS). Examinations were performed on 304 MCAs from 152 brains of human fetuses ranging from the 12th to 40th weeks of gestation. MCAs were analyzed with respect to its branching from the internal carotid artery and its division into...
The morphometrical and volumetrical changes of the middle cerebral artery (MCA) during the fetal period of development were analyzed by digital-image analysis system (DIAS). Examinations were performed on 304 MCAs from 152 brains of human fetuses ranging from the 12th to 40th weeks of gestation. MCAs were analyzed with respect to its branching from the internal carotid artery and its division into...
Many types of neural progenitors from different sources have been tested for experimental therapy in CNS injuries. We have established neural stem cell line from human cord blood (HUCB-NSC). In vitro evidence has suggested that HUCB-NSC are not immunogenic however their transplantation (tx) into adult rats led to the graft cell rejection. The question arises what is the nature of the host immune response...
Transplantation (tx) of neural stem cells (NSC) is the key strategy of cell replacement therapy in the central nervous system. The goal of the study was to compare survival, migration and differentiation of HUCB-NSC after their tx into the brain of neonatal and adult Wistar rats. Methods: HUCB-NSC (2 × 104 ) labeled with CMFDA were tx into SVZ of the postnatal day 0 (P0) rats or into intact brain...
Neural stem cells (NSC) are potentially a promising treatment strategy for neurological diseases. There is a proof that intracerebral grafting of NSC can have restorative effects. Nevertheless, a major obstacle is the induction of a host-derived immune response followed by graft injection. The goal of the study was to analyze the fate of HUCB-NSC transplanted in injured rat brain. Methods: 2×104 HUCB-NSC...
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