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Mice with null mutations for metallothionein genes MT-1 and MT-2 were used to study the role that metallothionein plays in protecting cellular targets in vivo from oxidative stress. Wild-type (MT +/+ ) and MT-null (MT -/- ) mice were treated with either saline or zinc and exposed to two types of oxidative stress: γ-irradiation or 2-nitropropane. There was no alteration...
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