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Cell-based biosensors (CBBs) are becoming an important tool for biosecurity applications and rapid diagnostics. For current CBBs technology, cell immobilization and high throughput fabrication are the main challenges. To address these in this study, the feasibility of bioprinting cell-laden hydrogel to fabricate CBBs at high throughput was investigated and cell response was tracked by using lensless...
Cell printing is an emerging technology for engineering complex 3D tissue/organ structures. In this study, the proliferation of primary rat bladder smooth muscle cells (SMCs) in printed cell-laden collagen droplets was quantified. The results showed that the bioprinting system is capable of printing viable cells, while keeping their proliferation ability in a 3D collagen matrix.
In the past, most research on gene regulation has focused on transcriptional regulation and post-translational regulation. Recently, the post-transcriptional regulation by small non-coding RNAs has drawn much attention. This mode of regulation was found in both prokaryotes and eukaryotes. In this study, the authors integrate transcriptional and post-transcriptional regulation into four different kinds...
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