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Rapid separation and transfer of target cells from heterogeneous mixture to desired region have become a key issue in many biomedical applications. In this paper, we propose an approach to high speed cell transfer for sorting rare cells from a small population of samples accurately using a robotic manipulation system equipped with optical tweezers. A novel switching geometrical model is established...
In most manipulation techniques for optical tweezers, open-loop controllers are developed to move the laser source without consideration of the dynamic interaction between the cell and the manipulator of laser source. This technical note presents a simple PD control scheme for manipulation of cell using optical tweezers. We formulate a closed-loop setpoint control problem for optical tweezers and...
Microscopic optics and cameras are commonly used in micromanipulation or biomanipulation workstations since they provide a large spectrum of visual details and information. The visual feedback information also improves robustness to uncertainty and accuracy of micromanipulation. Among various micromanipulation systems, optical tweezers are one of the most useful instruments that utilize a focused...
Optical tweezer is a useful tool for non-contact micromanipulation tasks because it can manipulate biological cells precisely without causing damage to the cells. In many optical manipulation techniques, the measurement of the velocity of the cell is necessary. Since it is difficult to measure the velocity of the cell, the velocity information is usually obtained by differentiating the position of...
Due to high quality factor and small mode volume, optical whispering gallery microcavities have been employed for fundamental studies of light-matter interaction and significant applications such as low-threshold laser devices, dynamic filters [1], and recently label-free ultra-sensitive biosensors [2]. Here, we demonstrate a novel material composition together with effective methods to fabricate...
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