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The transmembrane glycoprotein signal regulatory protein/SHP2-substrate (SIRP1α/SHPS-1) has been implicated in growth factor- and cell adhesion-induced signalling. Here we report on the contribution of SIRP1α to IL-6 type cytokine signalling. SIRP1α binds the protein tyrosine phosphatase SHP2 upon treatment with interleukin-6 in a stimulation-dependent manner. Mouse embryonic fibroblasts expressing...
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