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Recent progress in the development of high-resolution imaging techniques and reporter probes is expected to revolutionize molecular imaging research in animal models of human disease and, ultimately, clinical practice. These developments provide inroads to continuous monitoring and quantitation of gene delivery and gene expression during experimental gene therapy. Furthermore, techniques using novel...
Imaging techniques are currently being developed to map the topography and level of gene expression following gene therapy. To date, two different imaging strategies have been investigated - using marker genes encoding either intracellular enzymes or cell-surface receptors. The first approach employs the ability of certain enzymes to modify imaging prodrugs, so that tissue accumulation of such drugs...
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