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The present work is the first to deal with the determination of cholesterol synthesis rates in primary rat hepatocytes using transient 13 C-flux analysis. The effects of statins on cholesterol biosynthesis and central carbon fluxes were quantified at a therapeutic concentration of 50nM atorvastatin using carbon-labeled glutamine. The flux through the cholesterol pathway decreased from 0.27...
This paper examines the validity of the linlog approach, which was recently developed in our laboratory, by comparison of two different kinetic models for the metabolic network of Escherichia coli. The first model is a complete mechanistic model; the second is an approximative model in which linlog kinetics are applied. The parameters of the linlog model (elasticities) are derived from the mechanistic...
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