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Trypanosoma rangeli's sialidase (TrSA) and Trypanosoma cruzi's trans‐sialidase (TcTS) are members of the glycoside hydrolase family 33 (GH‐33). They share 70% of sequence identity and their crystallographic Cα RMSD is 0.59 Å. Despite these similarities they catalyze different reactions. TcTS transfers sialic acid between glycoconjugates while TrSA can only cleave sialic acid from sialyl‐glyconjugates...
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