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Cell-penetrating peptides (CPPs) are short membrane-permeating amino acid sequences that can be used to deliver cargoes, e.g. drugs, into cells. The mechanism for CPP internalization is still subject of ongoing research. An interesting family of CPPs is the sweet arrow peptides – SAP(E) – which are known to adopt a polyproline II helical secondary structure. SAP(E) peptides stand out among CPPs because...
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