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Photoacoustic tomography (PAT) was presented to in vivo monitor neovascularization in tumor angiogenesis with high resolution and high contrast images in a rat. With a circular scan system, the photoacoustic signal, generated by laser pulses at a wavelength of 532 nm from a Q-switched Nd:YAG laser, is captured through of a hydrophone with a diameter of 1 mm and a sensitivity of 850 nV/Pa. The vascular...
A photoacoustic tomography system is developed by using a double-ring sensor featuring a narrow angular aperture. An angular aperture of 2.0 degree can be obtained with this sensor, which improves the spatial resolution of the sensor in scanning direction. In this sensor a fiber for illumination of the sample is integrated, which enables reflection-mode detection of ultrasonic waves. These give the...
Gold nanoshell was used as a new contrast-enhancing agent for photoacoustic tomography. Gold nanoshells are concentric sphere nanoparticles consisting of a dielectric silica core and a gold shell. By varying the relative thickness of the core and shell layers, the plasmon-derived optical resonance of gold can be dramatically shifted in wavelength from the visible region into the infrared over a wavelength...
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