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MicroRNA-452 (miRNA-452) was overexpressed in docetaxel-resistant human breast cancer MCF-7 cells (MCF-7/DOC). However, its role in modulating the sensitivity of breast cancer cells to docetaxel (DOC) remains unclear. The aim of this study is to investigate the role of miRNA-452 in the sensitivity of breast cancer cells to DOC. Real-time quantitative PCR (RT-qPCR) were used to identify the differential...
Transmission Line Pulse (TLP) curve of high voltage SCR-LDMOS (SCR embedded in LDMOS) is measured under various repetitious TLP stress to evaluate its Electrostatic Discharge (ESD) protection capability. Results show that trigger voltage has walk-in behavior. TCAD simulation indicates its mechanism involved is explained by a base push-out effect dominated melt filament growth, that turns a robust...
A capacitance coupling complementation silicon controlled rectifies (CCCSCR) for electrostatic discharge (ESD) protection application is proposed and verified in 0.5μm BCD process. Compared with traditional complementation silicon controlled rectifies (CSCR), the CCCSCR has a lower trigger voltage. The coupling capacitance, as a tunable trigger of SCR, can meet different protection application demands...
MOS-Triggered Silicon Controlled Rectifier(SCR) has been used as on chip Electrostatic Discharge (ESD) protection. However, the inherit slow turn-on speed is a major drawback of SCR. The compact MOS-Triggered SCR devices have been proposed and investigated in a 0.13μm CMOS process with the consideration of turn-on speed. From the test results, the turn on time of compact MOS-Triggered SCR has improved...
A novel substrate-trigger GGNMOS structure with increasing the substrate resistance and pumping substrate trigger current using the VDD bus line controlled PMOS is proposed and verified in 65 nm CMOS process. The trigger voltage can be significantly reduced to ~3 V to safely protect the ultrathin gate oxide. The proposed structure has lower overshoot voltage which is helpful to protect the ultrathin...
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