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The assembly of amyloid peptides into highly organized fibrils is one of the major characteristics of many degenerative diseases such as Alzheimer's disease and type II diabetes. Assembly structures of amyloid peptides at liquid‐solid interface can be visualized by scanning tunneling microscopy (STM) with site‐specific resolution. The STM analysis can provide valuable information on the folding mechanism...
The TAR DNA-binding protein 43 (TDP-43) has been identified as a critical player in a range of neurodegenerative diseases, including frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). Recent discoveries demonstrate the important role of carboxyl-terminal fragments of TDP-43 in its proteinopathy. Herein, we report the characterization of β-domains in the C-terminal fragments...
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