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Starvation therapy kills tumor cells via consuming glucose to cut off their energy supply. However, since glucose oxidase (GOx)‐mediated glycolysis is oxygen‐dependent, the cascade reaction based on GOx faces the challenge of a hypoxic tumor microenvironment. By decomposition of glycolysis production of H2O2 into O2, starvation therapy can be enhanced, but chemodynamic therapy is limited. Here, a...