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We examined the immunotherapeutic ability of activated B cells which hound to anti-CD3 monoclonal antibody (mAb) to enhance antitumor T cell immunity in vivo . A flow cytometric analysis revealed that LPS (lipopolysaccharide)-activated B cells (LPS blasts) expressed Fc receptor (FcR) which can bind to anti-CD3 mAb, LPS blasts were also stained with CTLA-4Ig, which can bind to costimulation molecules...
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