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Glitazones are known to modulate fatty acid-induced effects on insulin secretion in the pancreatic β-cell. The present study focused on combined effects of troglitazone and oleate on preproinsulin (PPI) biosynthesis. Insulin-producing INS-1 cells were incubated for 4hr at 11.2mM glucose in the presence (O + ) or absence (O - ) of 200μM oleate with (T + ) or without (T -...
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