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Whole body synthesis of F 2 -isoprostanes, a family of cyclooxygenase-independent eicosanoids formed by free-radical catalysed peroxidation, should be best assessed by quantifying their urinary metabolites. Two methods for the quantitative determination of F 2 -isoprostane metabolites in human urine performing either thin-layer chromatography (TLC) (method A) or high-performance liquid...
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