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The present study investigates the action of zinterol at β3-adrenoceptors. We used mouse primary brown adipocytes and Chinese hamster ovary (CHO-K1) cells expressing the mouse or human β3-adrenoceptor. Zinterol was a full agonist at increasing cyclic AMP levels in primary brown adipocytes (which express β1- and β3-adrenoceptors but not β2-adrenoceptors), and this effect was almost totally abolished...
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