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Protection of the enzyme acetylcholinesterase (AChE) from the toxic effects of organophosphate insecticides and chemical warfare agents (OPs) may be provided by inhibitors that bind at the peripheral binding site (P‐site) near the mouth of the active‐site gorge. Compounds that bind to this site may selectively block access to the acylation site (A‐site) catalytic serine for OPs, but not acetylcholine...
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