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Activated glia, as a result of chronic inflammation, are associated with amyloid-β peptide (Aβ) deposits in the brain of Alzheimer's disease (AD) patients. In vitro, glia are activated by Aβ inducing secretion of pro-inflammatory molecules. Recent studies have focused on soluble oligomers (or protofibrils) of Aβ as the toxic species in AD. In the present study, using rat astrocyte cultures, oligomeric...
To investigate the consequences of complement activation on neuronal viability, the effects of serum treatment on neuron-rich and mixed neuronal/glial cultures were evaluated. The neurotoxicity observed following treatment with either human or rat serum was variable and did not appear to be mediated through a complement-mediated mechanism. Serum lots lacking CH 50 activity induced neurotoxicity,...
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