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A series of 3′-(substituted phenyl)deschloroepibatidine analogs (5a–j) were synthesized. The α4β2 ∗ and α7 nicotinic acetylcholine receptor (nAChR) binding properties and functional activity in the tail-flick, hot-plate, locomotor, and body temperature tests in mice of 5a–j were compared to those of the nAChR agonist, nicotine (1), epibatidine (4), and deschloroepibatidine (13), the partial...
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