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The 2,3-dihydrospiro[4H-thiopyrano[2,3-b]pyridin-4,4′-imidazolidine]-2′,5′-dione 3 and its 7-methyl analogue 4 were synthesized and tested for their ability to inhibit aldose reductase (ALR2). To expand the structure–activity relationships, the sulfone 5 and the acetic acid derivative 7 were also prepared and tested. Compounds 3 and 4 proved to be potent ALR2 inhibitors, with IC 50 values...
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