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Severe dengue virus (DENV) infection is epidemiologically linked to pre-existing anti-DENV antibodies acquired by maternal transfer or primary infection. A possible explanation is that DENV immune complexes evade neutralization by engaging Fcγ receptors (FcγR) on monocytes, natural targets for DENV in humans. Using epitope-matched humanized monoclonal antibodies (mAbs) and stable FcγR-transfected...
We have previously shown that the L1 major capsid protein of low-risk HPV11 binds to the Kap α2 adapter and enters the nucleus via a Kap α2β1-mediated pathway. In this study, we discovered that HPV11 L1 capsomeres bind to Kap β2 import receptor, known to mediate nuclear import of hnRNP A1 via interaction with its nuclear localization signal termed M9. Significantly, binding of HPV11 L1 capsomeres...
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