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We previously identified angiotensin converting enzyme (ACE) and an endopeptidase activity that degraded angiotensin-(1–7) [Ang-(1–7)] to Ang-(1–5) and Ang-(1–4), respectively, in the cerebrospinal fluid (CSF) of 6-month old male sheep. The present study undertook a more comprehensive analysis of the CSF peptidase that converts Ang-(1–7) to Ang-(1–4) in control and in utero betamethasone-exposed sheep...
Glucocorticoids including betamethasone (BM) are routinely administered to women entering into early preterm labor to facilitate fetal lung development and decrease infant mortality; however, fetal steroid exposure may lead to deleterious long term consequences. In a sheep model of fetal programming, BM-exposed (BMX) offspring exhibit elevated mean arterial pressure (MAP) and decreased baroreflex...
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