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Acute kidney injury (AKI) in mice caused by sustained ischemia followed by reperfusion is associated with acute tubular necrosis and renal dysfunctional blood flow. Although the principal role of the kidney is the maintenance of acid–base balance, current imaging approaches are unable to assess this important parameter, and clinical biomarkers are not robust enough in evaluating the severity of kidney...
PurposeTo investigate in vivo possible pH level alterations following an acute renal failure disease using a MRI‐CEST pH responsive contrast agent. The impact of functional evolution in different renal compartments over time was also investigated.
Methodsa mouse model of acute kidney injury was obtained by glycerol‐induced rhabdomyolysis. pH maps were obtained using Iopamidol (0.75 g iodine/kg b...
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