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Yeast RAD2, a counterpart of human XPG, is an essential gene for nucleotide excision repair. Rad2p is an endonuclease that incises the 3′ side of a DNA damaged lesion. However, over-expression of Rad2p provokes cell growth arrest, resulting in mitotic catastrophe as evidenced by formation of enlarged cells and micro-nucleation. Interestingly, the effect of Rad2p on cell growth arrest is not caused...
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