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Oxidized β-carotene (OBC) has been shown to have pro-oxidant and pro-carcinogenic effects. We recently reported that OBC induces oxidative DNA damage, measured as 8-hydroxy-deoxyguanosine (8-oxo-dG), in both calf thymus DNA and cellular DNA. However, the mechanism by which OBC induces the formation of 8-oxo-dG is unclear. To examine the hypothesis that reactive oxygen species (ROS), produced by BC...
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