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The ethyl acetate extracts from sweet orange peel (EESP) and its bioactive compounds against human hepatoma cells, in vitro and in vivo, is investigated. EESP (50–500µg/ml) exhibits significant cytotoxicity on HepG2 cells. This antiproliferative action is partly attributable to cell cycle arrest in the G0/G1 phase and apoptosis induction. EESP induces apoptosis through an increase in the Bax/Bcl-2...
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